Nasal Drop Presentation

Sodium Chloride IP	0.65 % w/v
Benzalkonium chloride IP	0.01% w/v

Nasal drops are the sterile, aqueous solution which are used to instill in the nose cavity. They are made isotonic with the body fluid. Mainly they are used to treat allergy caused by bacteria they act by restoring moisture to the dry air passages. saline solution, causes the blood vessels in the nose to contract and dilutes mucus and reduces swelling in the sinus area. Sodium chloride is used to produce sputum from the mouth and help in improving lung functions whereas benzalkonium chloride is used as a preservative to kill many bacteria.

Indications

1. Benzalkonium chloride is used as surfactant, in antiseptic creams, anti- itch ointments
2. Used in ophthalmic preparations
3. Sodium chloride is used as electrolyte which regulates water in the body and prevents dehydration
4. As antiseptic

Mechanism of Action

Sodium Chloride

Intranasal sodium chloride or saline solution is a purified salt solution used for providing moisture to the passages. and helps dissolve and loosen thick mucus. It is especially useful for decongestion passages.

Benzalkonium Chloride

Benzalkonium Chloride is primarily used as a preservative and antimicrobial agent, and secondarily used as a surfactant. It acts as a bactericidal and bacteriostatic action. It is used in antibacterial hand wipes, antiseptic creams and anti-itch ointments. In cosmetics, it is mostly used in personal care products like rash cream, facial lotion, cleanser, makeup and sunscreen.

Side Effects

1. Nausea
2. Vomiting
3. Diarrhoea
4. Congestion
5. Irritation in the eyes
6. Restlessness
7. Convulsions
8. Twitching of the muscles

Contraindications

1. Contraindicated in renal disease
2. Contraindicated in pregnancy

Precautions

1. Do not swallow this medication
2. Keep it away from the children

Drug Interactions

1. Terbutaline
2. Indomethacin
3. Seprafilm
4. Oxytocin
5. Dextranomer
6. Carboxymethylcellulose